代谢阻断型紫杉醇类似物的合成
Synthesis of metabolically blocked paclitaxel analogues.
作者信息
Wittman M D, Altstadt T J, Fairchild C, Hansel S, Johnston K, Kadow J F, Long B H, Rose W C, Vyas D M, Wu M J, Zoeckler M E
机构信息
Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA.
出版信息
Bioorg Med Chem Lett. 2001 Mar 26;11(6):809-10. doi: 10.1016/s0960-894x(01)00066-x.
Abstract
The stereospecific syntheses of the metabolically blocked 6-alpha-F, Cl, Br paclitaxel, and 6-alpha-F-10-acetyldocetaxel are described and in vitro and in vivo activity is presented.
摘要
描述了代谢受阻的6-α-氟、氯、溴紫杉醇以及6-α-氟-10-乙酰基多西他赛的立体定向合成，并展示了其体外和体内活性。
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