Novel inhibitors of the enzyme estrone sulfatase (ES).
作者信息
Ahmed S, James K, Owen C P, Patel C K, Patel M
机构信息
School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK.
出版信息
Bioorg Med Chem Lett. 2001 Mar 26;11(6):841-4. doi: 10.1016/s0960-894x(01)00086-5.
Abstract
We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.
摘要
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