Rao G
University of Pittsburgh Medical Center-St. Margaret, Pennsylvania 15215, USA.
Am Fam Physician. 2001 Mar 15;63(6):1159-63, 1165-6.
Insulin resistance can be linked to diabetes, hypertension, dyslipidemia, cardiovascular disease and other abnormalities. These abnormalities constitute the insulin resistance syndrome. Because resistance usually develops long before these diseases appear, identifying and treating insulin-resistant patients has potentially great preventive value. Insulin resistance should be suspected in patients with a history of diabetes in first-degree relatives; patients with a personal history of gestational diabetes, polycystic ovary syndrome or impaired glucose tolerance; and obese patients, particularly those with abdominal obesity. Present treatment consists of sensible lifestyle changes, including weight loss to attain healthy body weight, 30 minutes of accumulated moderate-intensity physical activity per day and increased dietary fiber intake. Pharmacotherapy is not currently recommended for patients with isolated insulin resistance.
胰岛素抵抗与糖尿病、高血压、血脂异常、心血管疾病及其他异常情况相关。这些异常情况构成了胰岛素抵抗综合征。由于胰岛素抵抗通常在这些疾病出现之前很久就已发生，识别并治疗胰岛素抵抗患者具有潜在的重大预防价值。对于一级亲属有糖尿病病史的患者；有妊娠期糖尿病、多囊卵巢综合征或糖耐量受损个人史的患者；以及肥胖患者，尤其是腹部肥胖者，应怀疑存在胰岛素抵抗。目前的治疗包括合理的生活方式改变，如减重以达到健康体重、每天累计进行30分钟中等强度体育活动以及增加膳食纤维摄入量。目前不建议对单纯胰岛素抵抗患者进行药物治疗。
