与喷他脒相关的芳香二脒和二咪唑啉的体外抗菌活性。
In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine.
作者信息
Donkor I O, Clark A M
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee, Memphis 38163, USA.
出版信息
Eur J Med Chem. 1999 Jul-Aug;34(7-8):639-43. doi: 10.1016/s0223-5234(00)80032-x.
Abstract
Geometric isomers of pentamidine analogues were screened for antimicrobial activity in vitro. cis isomers demonstrated good antibacterial activity compared to their trans counterparts. Both isomers were moderately active against opportunistic pathogens that afflict AIDS patients with minimum inhibitory concentrations in the range of 3.12-12.5 microg/mL.
摘要
对喷他脒类似物的几何异构体进行了体外抗菌活性筛选。与反式异构体相比，顺式异构体表现出良好的抗菌活性。两种异构体对感染艾滋病患者的机会性病原体均有中等活性，最低抑菌浓度范围为3.12 - 12.5微克/毫升。
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