Fukaya K, Kunii O, Mashimo K, Kitamoto O
Jpn J Antibiot. 1975 Feb;28(1):61-6.
The absorption and excretion of a new doxycycline solution for intravenous use (DOTC iv) were studied with the following results. 1. Serum levels following one shot intravenous injection of DOTC iv in glucose solution showed a good dose-response comparable with that of the same dose injection of pyrrolidinomethyltetracycline (PRM-TC). The urinary excretion was also examined. In 200 mg injection, nausea, general warm feeling, odor in mouth and tongue numbness were complained. 2. When DOTC iv was injected intramuscularly, the serum level did not reach the peak value and low level continued for a long time. Moderate local pain was complained at the site of injection. 3. The serum level following drip infection of DOTC dry fill showed a dose-response as well. The local vein tolerated well. 4. No abnormalities were found in clinical and laboratory examinations in all volunteers.
对一种新的静脉用强力霉素溶液（DOTC iv）的吸收和排泄进行了研究，结果如下。1. 在葡萄糖溶液中单次静脉注射DOTC iv后的血清水平显示出良好的剂量反应，与相同剂量注射吡咯烷甲基四环素（PRM-TC）相当。还检查了尿排泄情况。注射200毫克时，出现恶心、全身温热感、口腔异味和舌麻木等症状。2. 当肌肉注射DOTC iv时，血清水平未达到峰值，且长时间维持在低水平。注射部位有中度局部疼痛。3. DOTC干填充剂滴注后的血清水平也显示出剂量反应。局部静脉耐受性良好。4. 所有志愿者的临床和实验室检查均未发现异常。
