Thomas C B, Ross D C, Duszynski K R
Johns Hopkins Med J. 1975 May;136(5):193-208.
Hypercholesteremic medical students were different from their normocholesteremic classmates in a variety of ways. When students are grouped by cholesterol level in medical school, gradients across the means of biological, physiological, physical, and psychological characteristics are found. The hypercholesteremic students were older, shorter, and heavier, with younger mothers, less depression, less anxiety and less overall nervous tension under stress. Compared with their normocholesteremic classmates, youthful hypercholesteremics were more than 30 times as susceptible to episodes of acute myocardial infarction occurring 13 to 21 years after the high cholesterol levels were measured. Ten male medical students who subsequently sustained a myocardial infarction, most of whom were known to have had hypercholesteremia in youth, were significantly different at the outset from their 103 hypercholesteremic classmates who have not had such an episode. On the average, the precoronary individuals in medical school were shorter in stature, were older, had more overall nervous tension under stress, were more tired on awakening and had lower academic standing. The combination of hypercholesteremia and a personality profile denoting sensitivity and vulnerability to stress best characterizes this group of ten subjects who sustained a myocardial infarction at an early age. These findings suggest that it may be possible to differentiate young hypercholesteremics who are highly susceptible to myocardial infarction from their hypercholesteremic peers with relatively low susceptibility on the basis of personality profile.
高胆固醇血症的医学生在很多方面与胆固醇正常的同学不同。在医学院校，当学生按胆固醇水平分组时，会发现生物、生理、身体和心理特征均值存在梯度变化。高胆固醇血症的学生年龄更大、身高更矮、体重更重，其母亲年龄更小，压力状态下抑郁、焦虑程度更低，总体神经紧张程度也更低。与胆固醇正常的同学相比，年轻时就患有高胆固醇血症的学生在测量到高胆固醇水平13至21年后发生急性心肌梗死的易感性是前者的30多倍。10名后来发生心肌梗死的男医学生，其中大多数已知年轻时患有高胆固醇血症，他们从一开始就与103名未发生此类情况的高胆固醇血症同学有显著差异。医学院校中处于冠心病前期的个体平均身高更矮、年龄更大、压力状态下总体神经紧张程度更高、醒来时更疲惫且学业成绩更低。高胆固醇血症与表示对压力敏感和易受影响的人格特征相结合，最能描述这10名早年发生心肌梗死的受试者群体。这些发现表明，基于人格特征，有可能将极易患心肌梗死的年轻高胆固醇血症患者与其易感性相对较低的高胆固醇血症同龄人区分开来。
