Gemer M, Dunegan L J, Lehr J L, Bruner J D, Stetz C W, Don H F, Hayes J A, Drinker P A
J Thorac Cardiovasc Surg. 1975 May;69(5):793-9.
Most previous studies of the efficiency of bypass techniques for respiratory support have been conducted in hypoxic but otherwise normal animals. However, mechanisms of improved oxygenation by partial venoarterial bypass in the presence of acute respiratory insufficiency can be better studied with an appropriate pathophysiologic model; for this purpose, acute hemorrhagic pulmonary edema was induced in sheep by injection of oleic acid into the right atrium. The model presented a 3 hour period of elevated pulmonary shunting with stable hemodynamics. This preparation is being employed to the study of the mechanisms of extracorporeal oxygenation.
以往大多数关于呼吸支持旁路技术效率的研究都是在缺氧但其他方面正常的动物身上进行的。然而，在急性呼吸功能不全的情况下，通过部分静脉-动脉旁路改善氧合的机制可以通过合适的病理生理模型进行更好的研究；为此，通过向绵羊右心房注射油酸诱导急性出血性肺水肿。该模型呈现出3小时肺分流增加且血流动力学稳定的阶段。这种制备方法正被用于研究体外氧合的机制。
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