Cobreces-García M J, Castañeda-Casado F J
Laboratorio Experimental, Cátedra de Anestesiología, Facultad de Medicina de Valladolid.
Rev Esp Anestesiol Reanim. 1997 Jan;44(1):3-6.
When lungs are damaged or affected by edema they behave differently from healthy lungs in the presence of drugs that can modify vascular reactivity.
To determine the effects of halothane and isoflurane on pulmonary edema induced by oleic acid in dogs.
Eighteen dogs were anesthetized with sodium pentothal. Hemodynamic and lung parameters as well as end-tidal gases were monitored. Pulmonary edema was induced with an injection of oleic acid (0.1 ml/kg). Five periods were studied: 1) before injection of oleic acid; 2) 90 min after injection; 3) 20 min after ventilation with 1 MAC halothane or isoflurane; 4) 20 min after 2 MAC ventilation with the assigned anesthetic, and 5) 20 min after withdrawal of anesthetic.
With halothane, cardiac output and arterial blood pressure decreased significantly. With isoflurane, arterial pressure decreased by way of changes in vascular resistance. Neither anesthetic affected hypoxic pulmonary vasoconstriction.
Neither anesthetic worsens arterial oxygenation in a model of pulmonary edema that is similar to adult respiratory distress.
当肺部受损或受水肿影响时，在存在可改变血管反应性的药物的情况下，其表现与健康肺部不同。
确定氟烷和异氟烷对油酸诱导的犬肺水肿的影响。
18只犬用硫喷妥钠麻醉。监测血流动力学和肺部参数以及呼气末气体。注射油酸（0.1 ml/kg）诱导肺水肿。研究了五个阶段：1）注射油酸前；2）注射后90分钟；3）用1个最低肺泡有效浓度（MAC）氟烷或异氟烷通气20分钟后；4）用指定麻醉剂进行2个MAC通气20分钟后，以及5）停用麻醉剂20分钟后。
使用氟烷时，心输出量和动脉血压显著降低。使用异氟烷时，动脉压通过血管阻力的变化而降低。两种麻醉剂均未影响低氧性肺血管收缩。
在类似于成人呼吸窘迫的肺水肿模型中，两种麻醉剂均未使动脉氧合恶化。
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