el-Zeftawy H, Heiba S I, Jana S, Rosen G, Salem S, Santiago J F, Abdel-Dayem H M
Saint Vincent's Catholic Medical Centers of New York, Section of Nuclear Medicine, Department of Radiology, New York Medical College, Valhalla, NY, USA.
Cancer Biother Radiopharm. 2001 Feb;16(1):37-46. doi: 10.1089/108497801750096005.
To assess the impact of repeated F-18 FDG studies on the management of patients with bone and soft tissue (B&S) sarcomas.
Twenty patients with B&S tissue tumors (11 M and 9 F age 17-72 years) had 52 F-18 FDG Dual Head Coincidence Imaging (DHCI) studies. 7 patients were followed for 6 months to 2 years clinically after removal of the primary tumor. Thirteen patients were evaluated for suspected recurrences. Patient's preparation, F-18 FDG injection and imaging procedure were done according to department protocol. Attenuation corrected images were interpreted visually by 3 trained physicians. Tumor to background ratios were calculated for all lesions.
In 13 patients having both studies, baseline FDG and CT/MRI were concordant in 8 patients, FDG detected more lesions in 3 patients but it did not detect 4 metastatic pulmonary nodules in 2 patients. Follow up studies showed stable disease in 10 patients while 6 patients who showed worsening disease needed to change their chemotherapy. Surgery was avoided in 2 patients and 2 patients showed improved response.
Repeated F-18 FDG DHCI examinations proved to have an impact on the clinical management of patients with malignant bone and soft tissue sarcoma. It helps to differentiate postoperative changes from local recurrence.
评估重复进行F-18 FDG检查对骨与软组织（B&S）肉瘤患者治疗的影响。
20例B&S组织肿瘤患者（11例男性，9例女性，年龄17 - 72岁）接受了52次F-18 FDG双头符合成像（DHCI）检查。7例患者在切除原发肿瘤后进行了6个月至2年的临床随访。13例患者因怀疑复发而接受评估。患者准备、F-18 FDG注射及成像程序均按照科室规程进行。由3名经过培训的医生对衰减校正图像进行视觉解读。计算所有病变的肿瘤与背景比值。
在13例同时进行两种检查的患者中，8例患者的基线FDG和CT/MRI结果一致，3例患者中FDG检测到更多病变，但2例患者中FDG未检测到4个肺转移结节。随访研究显示，10例患者病情稳定，而6例病情恶化的患者需要更改化疗方案。2例患者避免了手术，2例患者显示反应改善。
重复进行F-18 FDG DHCI检查对恶性骨与软组织肉瘤患者的临床治疗有影响。它有助于区分术后改变与局部复发。
