Abe T, Matsumoto K, Kuwazawa J, Toyoda I, Sasaki K
Department of Neurosurgery, Showa University School of Medicine, 5-8 Hatanodal 1, Shinagawa-ku, Tokyo 142-8666, Japan.
Headache. 1998 Nov-Dec;38(10):782-6. doi: 10.1046/j.1526-4610.1998.3810782.x.
The objectives of this study were to analyze the characteristics of headache in patients with pituitary adenoma and to investigate the mechanisms involved. Fifty-one patients (27 females and 24 males) with pituitary adenoma were examined. Nineteen (37.3%) of these patients (13 females and 6 males) had headache preoperatively. Most commonly, the headache was generalized (42.1%); overall headache was more frequent in the anterior half of the head (84.2%). Seventeen (89.5%) patients had bilateral headache. Headache was usually described as head heaviness (57.9%) and continuous (57.9%). Pulsating headache and dull pain were only reported by the female patients and were mostly intermittent. The mean age of patients with headache was younger than that of those without headache. Headache was more prevalent in patients with a prolactin-secreting adenoma (57.1%). There were no correlations between visual disturbances, hypopituitarism, tumor size, or cavernous sinus invasion and headache. Hemorrhagic pituitary adenoma in 4 (57.1%) of 7 patients did not always contribute to headache. The headache was improved after surgery in 14 (73.6%) of the 19 patients. In the male patients who survived postoperatively (5 of 6), headache was improved.
本研究的目的是分析垂体腺瘤患者头痛的特征，并探讨其相关机制。对51例垂体腺瘤患者（27例女性和24例男性）进行了检查。其中19例患者（13例女性和6例男性，占37.3%）术前有头痛症状。最常见的是全头痛（42.1%）；总体上，头痛在前头部更为常见（84.2%）。17例患者（89.5%）为双侧头痛。头痛通常被描述为头部沉重感（57.9%）且持续存在（57.9%）。搏动性头痛和钝痛仅在女性患者中出现，且大多为间歇性。有头痛症状的患者平均年龄比无头痛症状的患者年轻。分泌泌乳素的腺瘤患者中头痛更为普遍（57.1%）。视力障碍、垂体功能减退、肿瘤大小或海绵窦侵犯与头痛之间无相关性。7例患者中有4例（57.1%）的出血性垂体腺瘤并非总是导致头痛。19例患者中有14例（73.6%）术后头痛得到改善。在术后存活的男性患者中（6例中的5例），头痛也得到了改善。
