Rothrock J F
Ochsner Clinic, New Orleans, La., USA.
Headache. 1999 Oct;39(9):650-3. doi: 10.1046/j.1526-4610.1999.3909650.x.
To determine if the use of a uniform treatment pathway might be effective in treating patients with primary chronic daily headache.
Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone.
Twenty-two patients (67%) reported a 50% or greater reduction in headache days per month following initiation of treatment. Most positive treatment responses (17 [77%] of 22) were attributed to divalproex sodium.
Implementation of a uniform treatment pathway may result in significant clinical improvement in a sizable proportion of patients with chronic daily headache.
确定采用统一的治疗方案对原发性慢性每日头痛患者进行治疗是否有效。
根据一种治疗方案对33例连续性原发性慢性每日头痛患者进行治疗,该方案包括依次给予丙戊酸二钠、阿米替林、阿米替林加苯乙肼或美沙酮。
22例患者(67%)报告治疗开始后每月头痛天数减少50%或更多。大多数积极的治疗反应(22例中的17例[77%])归因于丙戊酸二钠。
实施统一的治疗方案可能会使相当一部分慢性每日头痛患者的临床症状得到显著改善。