Shobha T R, Prakash O
Department of Medicine, St. Martha's Hospital, Bangalore 560 009.
J Assoc Physicians India. 2000 Dec;48(12):1197-9.
Puzzled by the observation of occurrence of transient glycosuria in several patients admitted with organophosphate and carbamate compound poisoning, we undertook a critical analysis of this observation.
Of the fifty-one consecutive patients admitted to the intensive care unit with organophosphate and carbamate compound poisoning, in 23 subjects the nature of the compound consumed was known; these were studied. The occurrence and duration of glycosuria, its magnitude, associated hyperglycemia if any, and correlation thereof were recorded.
Sixteen out of the 23 subjects (69%) demonstrated transient glycosuria. There were 13 men and 10 women. 10 subjects had euglycemia associated with glycosuria; 6 subjects had transient glycosuria with hyperglycemia (defined as random glucose over 160 mg%). None of the subjects had diabetes mellitus and the pre-hospital-discharge blood sugars were in the normal range.
Glycosuria (renal), albeit transient, was noted in a proportion of subjects admitted with organophosphate and carbamate poisoning. The exact etiology of this is unclear but in the light of recent literature, it is likely that oxidative stress at the renal tubular level leading to renal tubular damage may be the most likely explanation. Further, larger studies are needed to elucidate this is detail.
因观察到数例有机磷和氨基甲酸酯类化合物中毒患者出现短暂性糖尿，我们对此观察结果进行了批判性分析。
在连续入住重症监护病房的51例有机磷和氨基甲酸酯类化合物中毒患者中，23例患者摄入化合物的性质已知，对这些患者进行研究。记录糖尿的发生情况、持续时间、程度、是否伴有高血糖及其相关性。
23例患者中有16例（69%）出现短暂性糖尿。其中男性13例，女性10例。10例患者血糖正常但伴有糖尿；6例患者出现短暂性糖尿并伴有高血糖（定义为随机血糖超过160mg%）。所有患者均无糖尿病，出院前血糖均在正常范围内。
在部分有机磷和氨基甲酸酯中毒患者中发现了糖尿（肾性），尽管是短暂性的。其确切病因尚不清楚，但根据最近的文献，肾小管水平的氧化应激导致肾小管损伤可能是最有可能的解释。此外，需要进行更大规模的研究来详细阐明这一问题。
