Jerry N, Anitha Y, Sharma C P, Sony P
Department of Pharmaceutical Sciences, Medical College, Kerala, India.
Drug Deliv. 2001 Jan-Mar;8(1):19-23. doi: 10.1080/107175401300002711.
Alginate microspheres prepared by an emulsion-based process were loaded with insulin by a remote loading process. We observed that the time of exposure, pH of the remote loading medium, and beta-cyclodextrin complexation of insulin influenced drug loading. In vivo absorption studies of insulin from optimized microspheres were carried out in diabetic albino rats. Serum sugar levels on administration of multiple oral doses of the microspheres and a radioimmunoassay for serum insulin indicated absorption of insulin from the gastrointestinal region. This process could be utilized for the development of an oral insulin delivery system.
通过基于乳液的工艺制备的藻酸盐微球，采用远程加载法负载胰岛素。我们观察到暴露时间、远程加载介质的pH值以及胰岛素的β-环糊精络合作用会影响药物负载量。在糖尿病白化大鼠中对优化后的微球进行了胰岛素的体内吸收研究。给予多剂口服微球后的血清糖水平以及血清胰岛素放射免疫测定表明胰岛素从胃肠道区域被吸收。该工艺可用于开发口服胰岛素递送系统。
