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前列腺癌的诊断与治疗(作者译)

[Diagnostics and therapy of the carcinoma of the prostate (author's transl)].

作者信息

Schnorr D, Guddat H M, Neuser D, Correns H J, Dörner G, Mau S

出版信息

Zentralbl Chir. 1979;104(7):436-45.

PMID:112805
Abstract

By well organized preventive examinations early tumour stages can be recognized. The diagnosis of prostatic cancer has to be secured by biopsy. The primary reliability of aspiration biopsies (cytology) was 94% compared with punch biopsies (histology) amounting to 73%. Indications and results of aspiration biopsies, radiological and nuclear medical techniques in diagnosing prostatic cancer are described. The combined anti-androgenic hormonal therapy (infusions of cytonal, subcapsular orchiectomy, permanent administration of oestrogen) is considered to be the unchanged basis of treatment. Comparative cytologic investigations in therapy indicate that high-voltage treatment connected with hormonal therapy seems to be superior to exclusive hormonal treatment. Observations after additional therapy by a radionuclid (89-Strontium) for affecting metastases are encouraging. Indications of a therapy by cytostatica in progressive prostatic cancer are explained.

摘要

通过精心组织的预防性检查,可以识别早期肿瘤阶段。前列腺癌的诊断必须通过活检来确定。穿刺活检(细胞学)的初步可靠性为94%,而打孔活检(组织学)为73%。文中描述了穿刺活检、放射学和核医学技术在诊断前列腺癌方面的适应症和结果。联合抗雄激素激素治疗(静脉输注赛托宁、包膜下睾丸切除术、长期服用雌激素)被认为是治疗的不变基础。治疗中的比较细胞学研究表明,与激素治疗相结合的高压治疗似乎优于单纯的激素治疗。用放射性核素(锶-89)进行辅助治疗以影响转移灶后的观察结果令人鼓舞。文中解释了在进展性前列腺癌中使用细胞抑制剂进行治疗的适应症。

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