Nowicki M J, Subramony C, Bishop P R, Parker P H
Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA.
Am J Gastroenterol. 2001 Mar;96(3):788-92. doi: 10.1111/j.1572-0241.2001.03623.x.
Chicken skin mucosa is a newly described endoscopic finding associated with colonic neoplasms in adults. Chicken skin mucosa was sought in children with juvenile polyps to determine the prevalence, endoscopic features, and location. An alternative theory is proposed for the pathogenic mechanism of this finding.
Children having colonoscopy and polypectomy were prospectively evaluated for the presence of chicken skin mucosa. The location of the polyps was determined at colonoscopy; the size of removed polyps was measured during processing of samples in pathology. Biopsies from colonic chicken skin mucosa were stained with hematoxylin and eosin and mucicarmine.
Over a 1-yr period, 27 juvenile polyps were removed from 15 children at colonoscopy. Eleven of 15 children (73%) were found to have polyps with chicken skin mucosa; overall, 43% of the polyps had associated chicken skin mucosa. Chicken skin mucosa-positive polyps were larger than chicken skin mucosa-negative polyps and were only found in the rectosigmoid colon. Lipid-laden macrophages were found in all samples of chicken skin mucosa tested.
Chicken skin mucosa is a common finding in children with juvenile polyps. It probably is the result of local mucosal trauma, rather than a preneoplastic lesion.
鸡皮样黏膜是一种新描述的与成人结肠肿瘤相关的内镜表现。本研究旨在探寻患有幼年性息肉的儿童中鸡皮样黏膜的情况，以确定其患病率、内镜特征及部位。并针对这一表现的致病机制提出了另一种理论。
对接受结肠镜检查及息肉切除术的儿童进行前瞻性评估，以确定是否存在鸡皮样黏膜。在结肠镜检查时确定息肉的位置；在病理样本处理过程中测量切除息肉的大小。对结肠鸡皮样黏膜进行活检，并用苏木精-伊红和黏液卡红染色。
在1年的时间里，通过结肠镜检查从15名儿童中切除了27个幼年性息肉。15名儿童中有11名（73%）被发现息肉伴有鸡皮样黏膜；总体而言，43%的息肉伴有鸡皮样黏膜。鸡皮样黏膜阳性的息肉比鸡皮样黏膜阴性的息肉更大，且仅见于直肠乙状结肠。在所有检测的鸡皮样黏膜样本中均发现了富含脂质的巨噬细胞。
鸡皮样黏膜在患有幼年性息肉的儿童中很常见。它可能是局部黏膜创伤的结果，而非癌前病变。
