Liu H, MacKenzie-Graham A J, Kim S, Voskuhl R R
UCLA Dept. of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA.
J Neuroimmunol. 2001 Apr 2;115(1-2):118-26. doi: 10.1016/s0165-5728(01)00269-7.
The relationship between expression of the autoantigens in thymi and susceptibility to autoimmune disease was determined in the experimental autoimmune encephalomyelitis (EAE) model. In two different sets of MHC congenic strains of mice characterized by differential susceptibility to EAE, levels of expression of MBP were shown to be higher in the more resistant strain. These data raised the possibility that more central tolerance to MBP may occur in more resistant strains. Differential tolerance was then evidenced by a decrease in T cell responses to MBP 83-102 in the more resistant strains. Together, these data indicate that the list of non-MHC genes involved in susceptibility to autoimmune disease should include genes which regulate expression of autoantigens in thymi.
在实验性自身免疫性脑脊髓炎（EAE）模型中，确定了胸腺中自身抗原的表达与自身免疫性疾病易感性之间的关系。在两组对EAE易感性不同的MHC同基因小鼠品系中，髓鞘碱性蛋白（MBP）的表达水平在抗性更强的品系中更高。这些数据增加了在抗性更强的品系中可能对MBP产生更多中枢耐受的可能性。随后，在抗性更强的品系中，T细胞对MBP 83 - 102的反应降低，证明了存在差异耐受性。这些数据共同表明，参与自身免疫性疾病易感性的非MHC基因列表应包括调节胸腺中自身抗原表达的基因。
