Ashton P D, Curwen R S, Wilson R A
Dept. Biology, University of York, PO Box 373, YO10 5YW, York, UK.
Trends Parasitol. 2001 Apr;17(4):198-202. doi: 10.1016/s1471-4922(00)01947-4.
Parasite genome projects are generating an avalanche of sequence data. If this resource is to be exploited effectively for drug and vaccine design, there is an urgent need to make the link between these DNA sequences and the functional proteins of the parasite, which they encode. Here, we seek to demystify the revolutionary advances in protein identification based on mass spectrometry.
寄生虫基因组计划正在产生海量的序列数据。若要有效利用这一资源进行药物和疫苗设计,迫切需要在这些DNA序列与其所编码的寄生虫功能蛋白之间建立联系。在此,我们旨在揭开基于质谱的蛋白质鉴定方面的革命性进展的神秘面纱。