新生及去神经大鼠肌肉中乙酰胆碱受体动力学的性别差异。
Sex differences in the acetylcholine receptor kinetics of postnatal and denervated rat muscle.
作者信息
Villarroel A
机构信息
Department of Physiology and Biophysics, Dalhousie University School of Medicine, 3R1 Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7.
出版信息
J Physiol. 2001 Apr 1;532(Pt 1):175-80. doi: 10.1111/j.1469-7793.2001.0175g.x.
Single-channel recording from visualised endplates in freshly dissociated muscles from postnatal and denervated rat muscle revealed the presence of a low conductance, fetal type of acetylcholine receptor. Kinetic analysis showed a main component in the burst durations with a mean of 10.8 +/- 2.7 ms (n = 29). Receptors from female rats had an additional 27.3 +/- 5.5 ms (n = 5) kinetic component which was found in one-third of the 15 female endplates. Recordings from male and female denervated muscles gave more homogeneous kinetics with single time constants of 7.2 +/- 1.3 and 7.4 +/- 1.3 ms, respectively. It is concluded that the acetylcholine receptor channels present during early development are different from those of denervated muscle.
对新生和去神经支配的大鼠肌肉新鲜解离后可视化终板进行单通道记录，发现存在低电导的胎儿型乙酰胆碱受体。动力学分析显示爆发持续时间的主要成分平均为10.8±2.7毫秒（n = 29）。雌性大鼠的受体有一个额外的27.3±5.5毫秒（n = 5）动力学成分，在15个雌性终板中有三分之一可观察到。雄性和雌性去神经支配肌肉的记录给出了更均匀的动力学，时间常数分别为7.2±1.3和7.4±1.3毫秒。结论是早期发育过程中存在的乙酰胆碱受体通道与去神经支配肌肉的不同。
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