Gratton G, Goodman-Wood M R, Fabiani M
Department of Psychological Sciences, University of Missouri-Columbia, 65211, USA.
Hum Brain Mapp. 2001 May;13(1):13-25. doi: 10.1002/hbm.1021.
The noninvasive mapping of hemodynamic brain activity has led to significant advances in neuroimaging. This approach is based in part on the assumption that hemodynamic changes are proportional to (and therefore constitute a linear measure of) neuronal activity. We report a study investigating the quantitative relationship between neuronal and hemodynamic measures. This study exploited the fact that optical imaging methods can simultaneously provide noninvasive measures of neuronal and hemodynamic activity from the same region of the brain. We manipulated visual stimulation frequency and measured responses from the medial occipital area of 8 young adults. The results were consistent with a model postulating a linear relationship between the neuronal activity integrated over time and the amplitude of the hemodynamic response. The hemodynamic response colocalized with the neuronal response. These data support the use of quantitative neuroimaging methods to infer the intensity and localization of neuronal activity in occipital areas.
血流动力学脑活动的无创映射已在神经成像领域取得了重大进展。这种方法部分基于这样一种假设，即血流动力学变化与神经元活动成正比（因此构成神经元活动的线性度量）。我们报告了一项研究，该研究调查了神经元测量与血流动力学测量之间的定量关系。这项研究利用了光学成像方法可以同时从大脑同一区域提供神经元和血流动力学活动的无创测量这一事实。我们操纵视觉刺激频率，并测量了8名年轻人枕叶内侧区域的反应。结果与一个假设时间积分神经元活动与血流动力学反应幅度之间存在线性关系的模型一致。血流动力学反应与神经元反应共定位。这些数据支持使用定量神经成像方法来推断枕叶区域神经元活动的强度和定位。
