Kaneko K, Sakamoto K
Department of Communications and Systems, University of Electro-Communications, Japan.
Electromyogr Clin Neurophysiol. 2001 Mar;41(2):87-95.
In a study of spontaneous blinks, both electromyographic (EMG) activities from m. orbicularis oculi which is responsible for initiating closure of the eyelid and electro-oculogram (EOG) of vertical direction to the movement of the eyelid were measured in ten patients with Parkinson's disease and in thirty normal subjects. The aim of this study was to evaluate the generative mechanism of the spontaneous blinks by comparison of both the EMG and the EOG waveforms in the patients with Parkinson's disease and those in the normal subjects. The mean duration and the amplitude of both the EMG and the EOG were evaluated by the averaging of ten waveforms for the spontaneous blinks. The time lag between the onset of the generation of the EMG and the onset of the EOG signal was analyzed. The mean duration of the EMG and the mean amplitude of both the EMG and the EOG in the patients with Parkinson's disease were shorter and smaller than those in the normal subjects by the significant level of 1%, respectively. There was no difference of the time lag between the subject groups. These results suggest that the function of m. orbicularis oculi for the spontaneous blinks is reduced in patients with Parkinson's disease, because the motoneurones of the facial nucleus innervating the m. orbicularis oculi becomes hypoactive due to abnormal output of basal ganglia.
在一项关于自发眨眼的研究中，对10名帕金森病患者和30名正常受试者测量了负责启动眼睑闭合的眼轮匝肌的肌电图（EMG）活动以及与眼睑运动垂直方向的眼电图（EOG）。本研究的目的是通过比较帕金森病患者和正常受试者的EMG和EOG波形来评估自发眨眼的产生机制。通过对自发眨眼的10个波形进行平均来评估EMG和EOG的平均持续时间和幅度。分析了EMG产生开始与EOG信号开始之间的时间滞后。帕金森病患者的EMG平均持续时间以及EMG和EOG的平均幅度分别比正常受试者短且小，显著水平为1%。受试者组之间的时间滞后没有差异。这些结果表明，帕金森病患者眼轮匝肌的自发眨眼功能降低，因为支配眼轮匝肌的面神经核运动神经元由于基底神经节的异常输出而变得活动不足。
