Ohyama T, Oku H, Yoshida M, Katakai R
Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan.
Biopolymers. 2001 Jun;58(7):636-42. doi: 10.1002/1097-0282(200106)58:7<636::AID-BIP1036>3.0.CO;2-U.
A sequential polydepsipeptide, Boc-(Leu-Leu-Lac)3-Leu-Leu-OEt (1) (Lac = L-lactic acid residue) has been synthesized by the segment condensation method. The sequential unit of 1, -Leu-Leu-Lac-, is consisted of two amino acid residues and one hydroxy acid residue. X-ray diffraction measurement with an imaging plate detector and a direct-methods procedure of Shake-and-Bake successfully revealed the crystal structure of 1. In the solid state, the 11-mer depsipeptide, 1, have clear alpha-helical conformation even with the three ester linkages.
通过片段缩合方法合成了一种序列型聚二肽Boc-(Leu-Leu-Lac)3-Leu-Leu-OEt (1)（Lac = L-乳酸残基）。1的序列单元-Leu-Leu-Lac-由两个氨基酸残基和一个羟基酸残基组成。使用成像板探测器和Shake-and-Bake直接法程序进行的X射线衍射测量成功揭示了1的晶体结构。在固态下，即使含有三个酯键，这种11聚体二肽1仍具有清晰的α-螺旋构象。
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