Bruschke C J, Kamp E M, Boersma W, Stockhofe-Zurwieden N, Bouma A
Institut voor Dierhouderij en Diergezondheid, Postbus 65 8200 AB Lelystad.
Tijdschr Diergeneeskd. 2001 Mar 15;126(6):211-7.
To determine a possible relationship between the compulsory vaccination against bovine herpesvirus 1 (BHV1) and cattle wasting disease, the effects of BHV1 vaccination on heifers were investigated. Twenty heifers in the third trimester of pregnancy were randomly allotted to a vaccine and a control group. The vaccine group was vaccinated twice with a 50-fold dose of BHV1 vaccine and the control group was inoculated with the diluent. The experiment was performed double blind. After vaccination, the cows were examined daily and condition scores were determined weekly. Blood, milk, and faeces samples were collected weekly for virological, bacteriological, and immunological investigation. The heifers were euthanized either 9 or 13 weeks after the first inoculation and pathological, virological, and bacteriological examination was performed. No differences were detected between the vaccine group and the control group. No concurrent infections were detected and there were no indications of immunosuppression after vaccination. No relationship between the BHV1 vaccination and wasting disease in cattle was detected.
为确定强制接种牛疱疹病毒1型（BHV1）疫苗与牛消瘦病之间可能存在的关系，对BHV1疫苗接种对小母牛的影响进行了研究。将20头处于妊娠晚期的小母牛随机分为疫苗组和对照组。疫苗组用50倍剂量的BHV1疫苗接种两次，对照组接种稀释剂。实验采用双盲法进行。接种疫苗后，每天对奶牛进行检查，每周确定体况评分。每周采集血液、牛奶和粪便样本进行病毒学、细菌学和免疫学研究。在首次接种后9周或13周对小母牛实施安乐死，并进行病理学、病毒学和细菌学检查。未在疫苗组和对照组之间检测到差异。未检测到并发感染，接种疫苗后也没有免疫抑制的迹象。未发现BHV1疫苗接种与牛消瘦病之间存在关联。
