Ordovas J M
JM-USDA-Human Nutrition Research Center on Aging, Tufts University School of Medicine, 711 Washington Street, Boston, MA 02111, USA.
Curr Atheroscler Rep. 2001 May;3(3):200-8. doi: 10.1007/s11883-001-0062-3.
Research in the field of gene-diet interactions as determinants of plasma lipid response to dietary interventions has accumulated a substantial body of evidence during the past decade. Several candidate genes have shown some promise as potential markers of individual dietary responsiveness. Among the best characterized are the APOE, APOA4, APOB, APOC3, and LPL loci. Other genes are being continuously incorporated to this most interesting search. However, in very few cases has consensus been achieved about the usefulness of genetic markers as clinically significant predictors of dietary response. The increased ability to generate genotypic information, in combination with the knowledge from the human genome project and more comprehensive experimental designs, will dramatically improve our capacity to answer many of our current questions. It will also help to prove that knowledge of an individual's genetic background will facilitate more precise dietary counseling and intervention, and more efficacious primary and secondary coronary heart disease prevention.
在过去十年中，关于基因-饮食相互作用作为饮食干预后血浆脂质反应决定因素的研究积累了大量证据。几个候选基因已显示出作为个体饮食反应潜在标志物的一些前景。其中特征最明显的是载脂蛋白E（APOE）、载脂蛋白A4（APOA4）、载脂蛋白B（APOB）、载脂蛋白C3（APOC3）和脂蛋白脂肪酶（LPL）基因座。其他基因也在不断纳入这一极为有趣的研究中。然而，在极少数情况下，对于遗传标志物作为饮食反应临床显著预测指标的有用性达成了共识。生成基因型信息的能力增强，再加上人类基因组计划的知识和更全面的实验设计，将极大提高我们回答当前许多问题的能力。这也将有助于证明，了解个体的遗传背景将有助于更精确的饮食咨询和干预，以及更有效的原发性和继发性冠心病预防。
