动脉粥样硬化形成与精氨酸假说
Atherogenesis and the arginine hypothesis.
作者信息
Cooke J P, Oka R K
机构信息
Section of Vascular Medicine, Stanford University School of Medicine, CVRB Section, Floor South, Stanford, CA, 94305-5406, USA.
出版信息
Curr Atheroscler Rep. 2001 May;3(3):252-9. doi: 10.1007/s11883-001-0068-x.
PMID:11286647
Abstract
In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.
摘要
在血浆不对称二甲基精氨酸（ADMA）水平升高的患者中，已发现L-精氨酸相对缺乏会导致动脉粥样硬化的病理生理过程，引起血管收缩并加速动脉粥样硬化的发生。这一发现——动脉粥样硬化疾病中存在L-精氨酸相对缺乏——是一项将开辟新治疗途径的突破。
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