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肝移植受者感染管理的最新进展

Recent Advances in the Management of Infections in Liver Transplant Recipients.

作者信息

Singh Nina

机构信息

VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA.

出版信息

Curr Infect Dis Rep. 2001 Apr;3(2):123-130. doi: 10.1007/s11908-996-0034-4.

Abstract

Antimicrobial-resistant bacteria (vancomycin-resistant enterococci and Staphylococcus aureus) have emerged as leading pathogens in liver transplant recipients. Liver transplant recipients have also been shown to be uniquely more susceptible to harboring extended-spectrum beta-lactamase-producing Enterobacteriaceae. The frequency of mycelial fungal infections has increased; however, effective prophylaxis and management of these infections remains suboptimal. Emerging reports have highlighted the morbidity due to novel herpesviruses in these patients. Finally, the emergence of ganciclovir resistance in cytomegalovirus has implications relevant for all solid organ transplant recipients.

摘要

耐抗菌药物细菌(耐万古霉素肠球菌和金黄色葡萄球菌)已成为肝移植受者的主要病原体。肝移植受者还被证明特别更容易携带产超广谱β-内酰胺酶的肠杆菌科细菌。丝状真菌感染的频率有所增加;然而,对这些感染的有效预防和管理仍然不够理想。新出现的报告强调了这些患者中新型疱疹病毒导致的发病率。最后,巨细胞病毒中更昔洛韦耐药性的出现对所有实体器官移植受者都有影响。

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