Korner J, Eberle M A
Columbia University, Division of Endocrinology, 630 West 168th Street, Black Building Room 905, New York, NY 10032, USA.
Curr Rheumatol Rep. 2001 Apr;3(2):101-6. doi: 10.1007/s11926-001-0004-7.
Obesity and osteoarthritis are two commonly encountered clinical problems that can lead to significant physical and emotional disability. This report examines the association between obesity and osteoarthritis, and discusses potential mechanisms by which obesity influences osteoarthritis. Special attention is devoted to reviewing the molecular and genetic mechanisms that underlie the development of clinical obesity. Improved understanding of obesity will hopefully lead to improved treatment and subsequent amelioration of this important risk factor for osteoarthritis.
肥胖和骨关节炎是两个常见的临床问题，可导致严重的身体和情感残疾。本报告探讨肥胖与骨关节炎之间的关联，并讨论肥胖影响骨关节炎的潜在机制。特别关注回顾临床肥胖发生发展的分子和遗传机制。对肥胖有更深入的了解有望带来更好的治疗方法，并进而改善这一骨关节炎重要危险因素的状况。
