Los M, Stroh C, Jänicke R U, Engels I H, Schulze-Osthoff K
Dept of Immunology and Cell Biology, University of Münster, D-48149, Münster, Germany.
Trends Immunol. 2001 Jan;22(1):31-4. doi: 10.1016/s1471-4906(00)01814-7.
Proteases of the caspase family constitute the central executioners of apoptosis. Several recent observations suggest that caspases and apoptosis-regulatory molecules exert important functions beyond that of cell death, including the control of T-cell proliferation and cell-cycle progression. Here, Los and colleagues propose a model that directly connects cell suicide mechanisms to the regulation of cell-cycle progression.
半胱天冬酶家族的蛋白酶是细胞凋亡的核心执行者。最近的一些观察结果表明，半胱天冬酶和凋亡调节分子发挥着超出细胞死亡的重要功能，包括对T细胞增殖和细胞周期进程的控制。在这里，洛斯及其同事提出了一个将细胞自杀机制与细胞周期进程调节直接联系起来的模型。
