Mazoyer B, Zago L, Mellet E, Bricogne S, Etard O, Houdé O, Crivello F, Joliot M, Petit L, Tzourio-Mazoyer N
Groupe d'Imagerie Neurofonctionnelle, UMR6095, CNRS, LEA, Université de Caen, Université 5, Paris, France.
Brain Res Bull. 2001 Feb;54(3):287-98. doi: 10.1016/s0361-9230(00)00437-8.
The cortical anatomy of the conscious resting state (REST) was investigated using a meta-analysis of nine positron emission tomography (PET) activation protocols that dealt with different cognitive tasks but shared REST as a common control state. During REST, subjects were in darkness and silence, and were instructed to relax, refrain from moving, and avoid systematic thoughts. Each protocol contrasted REST to a different cognitive task consisting either of language, mental imagery, mental calculation, reasoning, finger movement, or spatial working memory, using either auditory, visual or no stimulus delivery, and requiring either vocal, motor or no output. A total of 63 subjects and 370 spatially normalized PET scans were entered in the meta-analysis. Conjunction analysis revealed a network of brain areas jointly activated during conscious REST as compared to the nine cognitive tasks, including the bilateral angular gyrus, the left anterior precuneus and posterior cingulate cortex, the left medial frontal and anterior cingulate cortex, the left superior and medial frontal sulcus, and the left inferior frontal cortex. These results suggest that brain activity during conscious REST is sustained by a large scale network of heteromodal associative parietal and frontal cortical areas, that can be further hierarchically organized in an episodic working memory parieto-frontal network, driven in part by emotions, working under the supervision of an executive left prefrontal network.
通过对9种正电子发射断层扫描（PET）激活方案进行荟萃分析，研究了清醒静息状态（REST）的皮质解剖结构，这些方案处理不同的认知任务，但都将REST作为共同的对照状态。在REST期间，受试者处于黑暗和安静环境中，并被要求放松、避免移动以及避免系统性思维。每个方案都将REST与不同的认知任务进行对比，这些认知任务包括语言、心理意象、心算、推理、手指运动或空间工作记忆，使用听觉、视觉或无刺激传递方式，并要求发声、运动或无输出。共有63名受试者和370次空间归一化PET扫描被纳入荟萃分析。联合分析揭示了与这9种认知任务相比，在清醒REST期间共同激活的脑区网络，包括双侧角回、左侧前楔叶和后扣带回皮质、左侧内侧额叶和前扣带回皮质、左侧额上沟和额中沟以及左侧额下回皮质。这些结果表明，清醒REST期间的脑活动由一个大规模的异模态联合顶叶和额叶皮质区域网络维持，该网络可在情景工作记忆顶叶-额叶网络中进一步进行层次组织，部分由情感驱动，并在执行性左侧前额叶网络的监督下工作。
