Bennett C M, Falkinburg N R, Springberg P D
Nephron. 1975;14(3-4):237-45. doi: 10.1159/000180453.
We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated following elevation of GFR 11-29 per cent by high protein diet and dexamethazone ingestion. In every casetubular reabsorption of bicarbonate increased in proportion to the increases in GFR. We conclude that glomerular-tubular balance for bicarbonate reabsorption is a characteristic of human, as well as canine kidneys.
我们最近在狗身上发现，重碳酸盐重吸收与肾小球滤过率（GFR）之间存在密切关系。本研究旨在在五名正常男性中证实这些发现。在摄入低蛋白饮食一周后进行重碳酸盐滴定，并在通过高蛋白饮食和地塞米松摄入使GFR升高11%-29%后重复进行。在每种情况下，重碳酸盐的肾小管重吸收均与GFR的增加成比例增加。我们得出结论，重碳酸盐重吸收的球管平衡是人类以及犬类肾脏的一个特征。
