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Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.
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The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.
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Mechanisms of cancer cell killing by the adenovirus E4orf4 protein.
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NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death.
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本文引用的文献
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Induction of apoptosis by adenovirus E4orf4 protein.
Apoptosis. 2000 Jun;5(3):211-5. doi: 10.1023/a:1009644210581.
2
Caspase activation by adenovirus e4orf4 protein is cell line specific and Is mediated by the death receptor pathway.
J Virol. 2001 Jan;75(2):789-98. doi: 10.1128/JVI.75.2.789-798.2001.
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Adenovirus E4orf4 protein interacts with both Balpha and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Balpha.
Oncogene. 2000 Aug 3;19(33):3757-65. doi: 10.1038/sj.onc.1203705.
4
Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.
J Virol. 2000 Sep;74(17):7869-77. doi: 10.1128/jvi.74.17.7869-7877.2000.
5
Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.
Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10080-5. doi: 10.1073/pnas.96.18.10080.
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The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.
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Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins.
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Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
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E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk.
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Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.
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