Kleinberger T
The Gonda Center of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Apoptosis. 2000 Jun;5(3):211-5. doi: 10.1023/a:1009644210581.
Adenovirus E4orf4 protein is a multifunctional viral regulator that induces p53-independent apoptosis in transformed cells, but not in normal cells. E4orf4-induced apoptosis can occur without activation of known caspases, although E4orf4 induces caspase activity in some cell lines. The interaction of E4orf4 with a specific subpopulation of protein phosphatase 2A (PP2A) molecules that contain B subunits, but not with those that contain B' subunits, is required for induction of apoptosis. This review suggests the potential use of E4orf4 in cancer therapy, and discusses whether E4orf4-induced apoptosis plays a role in the viral life cycle. Future research directions are also highlighted.
腺病毒E4orf4蛋白是一种多功能病毒调节因子，可在转化细胞中诱导不依赖p53的凋亡，但在正常细胞中则不会。尽管E4orf4在某些细胞系中可诱导半胱天冬酶活性，但E4orf4诱导的凋亡可在不激活已知半胱天冬酶的情况下发生。E4orf4与特定亚群的含有B亚基而非B'亚基的蛋白磷酸酶2A（PP2A）分子相互作用是诱导凋亡所必需的。本综述提出了E4orf4在癌症治疗中的潜在用途，并讨论了E4orf4诱导的凋亡是否在病毒生命周期中发挥作用。还强调了未来的研究方向。
