Gene therapy for HIV.
作者信息
Lever A M
机构信息
University of Cambridge Department of Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
出版信息
Sex Transm Infect. 2001 Apr;77(2):93-6. doi: 10.1136/sti.77.2.93.
Abstract
摘要
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本文引用的文献
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A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides.
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cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.F12人类免疫缺陷病毒（HIV）Nef等位基因的顺式表达将高生产性的1型HIV NL4-3毒株转变为复制缺陷型毒株：Env gp41和CD4胞质尾均参与其中。
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Transfer of human CD4(+) T lymphocytes producing beta interferon in Hu-PBL-SCID mice controls human immunodeficiency virus infection.在人外周血淋巴细胞-严重联合免疫缺陷（Hu-PBL-SCID）小鼠中产生β干扰素的人CD4(+) T淋巴细胞的转移可控制人类免疫缺陷病毒感染。
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Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model.在发夹状核酶转基因小鼠模型中对HIV-1/MuLV假型病毒的体外剂量反应抗性
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12749-53. doi: 10.1073/pnas.96.22.12749.
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Inhibition of replication of reactivated human immunodeficiency virus type 1 (HIV-1) in latently infected U1 cells transduced with an HIV-1 long terminal repeat-driven PKR cDNA construct.在由HIV-1长末端重复序列驱动的PKR cDNA构建体转导的潜伏感染U1细胞中，对重新激活的1型人类免疫缺陷病毒（HIV-1）复制的抑制作用。
J Virol. 1999 Nov;73(11):9021-8. doi: 10.1128/JVI.73.11.9021-9028.1999.
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Suppression of HIV-1 transcription and replication by a Vpr mutant.一种Vpr突变体对HIV-1转录和复制的抑制作用。
Gene Ther. 1999 May;6(5):947-50. doi: 10.1038/sj.gt.3300907.
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Inhibition of human immunodeficiency virus (HIV-1) replication in SupT1 cells transduced with an HIV-1 LTR-driven PKR cDNA construct.在由HIV-1长末端重复序列驱动的PKR cDNA构建体转导的SupT1细胞中对人类免疫缺陷病毒（HIV-1）复制的抑制作用。
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trans-dominant interference with human immunodeficiency virus type 1 replication and transmission in CD4(+) cells by an envelope double mutant.包膜双突变体对人类免疫缺陷病毒1型在CD4(+)细胞中复制和传播的反式显性干扰
J Virol. 1999 Oct;73(10):8290-302. doi: 10.1128/JVI.73.10.8290-8302.1999.
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Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intrabodies.在急性和持续感染的表达鼠源和人源化抗人免疫缺陷病毒1型Tat单链可变片段胞内抗体的人CD4+单核细胞中，体外抑制人免疫缺陷病毒1型复制。
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Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.HIV-1 Rev的功能同源物Sam68的显性负性突变体对HIV复制的抑制作用。
Nat Med. 1999 Jun;5(6):635-42. doi: 10.1038/9479.
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