McKinney A R, Ridley D D, Suann C J
Australian Racing Forensic Laboratory, P.O. Box 528, Kensington, New South Wales 1465, Australia.
J Mass Spectrom. 2001 Feb;36(2):145-50. doi: 10.1002/jms.111.
After oral administration to a thoroughbred gelding, the anabolic steroid norethandrolone was converted into a complex mixture of oxygenated metabolites. These metabolites were extracted from the urine, deconjugated by methanolysis and converted to their O-methyloxime trimethylsilyl derivatives. Gas chromatographic/mass spectrometric analysis indicated the major metabolites to be 19-norpregnane-3,16,17-triols, 19-norpregnane-3,17,20-triols and 3,17-dihydroxy-19-norpregnan-21-oic acids. Some minor metabolites were also detected.
给一匹纯种去势雄马口服同化类固醇诺乙雄龙后，它被转化为多种含氧化代谢物的复杂混合物。这些代谢物从尿液中提取出来，通过甲醇解作用进行去结合，并转化为它们的O-甲基肟三甲基硅烷基衍生物。气相色谱/质谱分析表明，主要代谢物为19-去甲孕烷-3,16,17-三醇、19-去甲孕烷-3,17,20-三醇和3,17-二羟基-19-去甲孕烷-21-酸。还检测到了一些次要代谢物。
