Atterhög J H, Ekelund L G
Minerva Med. 1975 May 26;66(39):1877-82.
After an intravenous injection of 0.1 mg Verapamil per kg body weight and during an infusion of 0.007 mg Verapamil per kg body weight and minute the heart rate increased, P,Q,-time increased, pulmonary vascular pressures increased. Aortic pressures decreased. No change in maximum dp/dt of the aortic pressure. The word maximum is still missing. Pre-ejection period decreased. During an exercise on a load of 650 kpm/min on average heart rate after Verapamil was increased, aortic pressures decreased, stroke work decreased and there were no signs of any negative inotropic effect.
静脉注射每千克体重0.1毫克维拉帕米后，在以每千克体重每分钟0.007毫克维拉帕米的速度输注期间，心率增加，P、Q间期增加，肺血管压力升高，主动脉压力降低。主动脉压力的最大dp/dt无变化。“最大”一词仍缺失。射血前期缩短。在平均负荷为650千帕米/分钟的运动期间，维拉帕米后的平均心率增加，主动脉压力降低，每搏功降低，且无任何负性肌力作用的迹象。
