Furlanello F, Piccolo E, Disertori M, Trevi G P, Lanzetta T
Minerva Med. 1975 May 26;66(39):1887-903.
Rapid and slow venous infusion of various doses of Verapamil in a mixed series of 185 cases of arrhythmia since 1968 is reported. Results and electrophysiological and ECG changes observed for each type of arrhythmia examined are considered separately: atrial fibrillation-flutter, supraventricular paroxystic tachycardia (atrial and/or junctional), and hyperkinetic ventricular arrhythmia. An association of i.v. Verapamil and a quinidine salt per os is suggested as an alternative to cardioversion in cases of recent atrial fibrillation-flutter. Results obtained in the treatment of arrhythmia due to electrical instability following angina and of angina following arrhythmia are also described. A study of His potentials as the premiss for using Verapamil in subjects with stimulus conductivity changes, including W.P.W. syndrome, is also reported. I.v. Verapamil was used in association with atrial and/or ventricular electrostimulation, and/or with electrical counter-shock in cases of arrhythmia (mostly supraventricular) that were especially refractory. Attention is drawn to the use of Verapamil in the control of arrhythmia after electrical cardioversion.
本文报道了自1968年以来，对185例心律失常患者进行不同剂量维拉帕米快速和缓慢静脉输注的情况。针对每种检查的心律失常类型（心房颤动-扑动、室上性阵发性心动过速（房性和/或交界性）以及室性心动过速）分别考虑其结果以及观察到的电生理和心电图变化。对于近期心房颤动-扑动患者，建议静脉注射维拉帕米与口服奎尼丁盐联合使用，作为心脏复律的替代方法。还描述了在治疗心绞痛后因电不稳定引起的心律失常以及心律失常后心绞痛方面所获得的结果。还报道了一项关于希氏束电位的研究，以此作为在包括预激综合征在内的刺激传导改变患者中使用维拉帕米的前提。静脉注射维拉帕米与心房和/或心室电刺激和/或在特别难治的心律失常（主要是室上性）病例中与电除颤联合使用。文中还提到了维拉帕米在心脏电复律后控制心律失常方面的应用。
