[Venous infusion of nerapamil in the treatment of refractory angina pectoris and arrhythmia due to associated electric instability].

The therapeutic effect of Verapamil in 45 patients with angina that had failed to respond to other drugs is described. Angina was distinguished in terms of its clinical and ECG features. Verapamil was administered i.v., usually in infusions of 10-250 mg/day over periods of hours or days; alternatively, direct injections of 2,5-5 mg were employed. The effect on arterial pressure is particularly stressed. In the great majority of cases, there was a marked improvement in the symptomatology and in arrhythmic changes arising during angina. The importance of the therapeutic effects of the drug is examined and its possible mechanisms of action are discussed.