Piccolo E, Furlanello F, Trevi G P, Pascotto P, Lanzetta T
Minerva Med. 1975 May 26;66(39):1865-73.
The therapeutic effect of Verapamil in 45 patients with angina that had failed to respond to other drugs is described. Angina was distinguished in terms of its clinical and ECG features. Verapamil was administered i.v., usually in infusions of 10-250 mg/day over periods of hours or days; alternatively, direct injections of 2,5-5 mg were employed. The effect on arterial pressure is particularly stressed. In the great majority of cases, there was a marked improvement in the symptomatology and in arrhythmic changes arising during angina. The importance of the therapeutic effects of the drug is examined and its possible mechanisms of action are discussed.
本文描述了维拉帕米对45例使用其他药物无效的心绞痛患者的治疗效果。根据临床和心电图特征对心绞痛进行了区分。维拉帕米通过静脉注射给药，通常以10 - 250毫克/天的剂量在数小时或数天内输注；或者直接注射2.5 - 5毫克。特别强调了其对动脉血压的影响。在绝大多数病例中，心绞痛症状及发作时出现的心律失常变化有明显改善。本文探讨了该药物治疗效果的重要性，并讨论了其可能的作用机制。
