Chokephaibulkit K, Srifuengfung S, Mingbanjerdsuk J, Tosasuk K, Vanprapar N, Chearskul S, Dhiraputra C
Departments of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 2000 Sep;31(3):498-505.
The antibiotic susceptibility pattern of Streptococcus pneumoniae isolated from specimens of invasive infections was examined at Siriraj Hospital, a tertiary care center in Bangkok, during December 1996 April 1998. The percentage of S. pneumoniae isolates intermediate and resistant to various antibiotics were: penicillin, 25% and 21%; amoxicillin-clavulanate, 24% and 0%; cefuroxime, 6% and 36%; cefotaxime, 6% and 1.4%; ceftibuten, 5% and 42%; imipenem 22% and 0%; co-trimoxazole, 6% and 41%; chloramphenicol, 2% and 26%; erythromycin, 12% and 16%; azithromycin, 0% and 30%; and roxithromycin 0% and 33%. Most of the penicillin-nonsusceptible S. pneumoniae (PNSP) were also nonsusceptible to other antibiotics except cefotaxime, and imipenem. The isolates from respiratory specimens have a higher rate of resistance to all antimicrobial agents with a significant rise in MIC50 of beta-lactam antibiotics. There was no difference in the outcome of infections caused by penicillin-susceptible and -nonsuscetible S. pneumoniae. The only identifiable risk factor associated with PNSP infection was prior use of antibiotic within 3 weeks.
1996年12月至1998年4月期间，在曼谷的一家三级医疗中心诗里拉吉医院，对从侵袭性感染标本中分离出的肺炎链球菌的抗生素敏感性模式进行了检测。对各种抗生素呈中介和耐药的肺炎链球菌分离株的百分比分别为：青霉素，25%和21%；阿莫西林-克拉维酸，24%和0%；头孢呋辛，6%和36%；头孢噻肟，6%和1.4%；头孢布烯，5%和42%；亚胺培南，22%和0%；复方新诺明，6%和41%；氯霉素，2%和26%；红霉素，12%和16%；阿奇霉素，0%和30%；罗红霉素，0%和33%。除头孢噻肟和亚胺培南外，大多数对青霉素不敏感的肺炎链球菌（PNSP）对其他抗生素也不敏感。呼吸道标本分离株对所有抗菌药物的耐药率更高，β-内酰胺类抗生素的MIC50显著升高。青霉素敏感和不敏感的肺炎链球菌引起的感染结果没有差异。与PNSP感染相关的唯一可识别危险因素是在3周内曾使用过抗生素。
