细菌中的硝酸盐和亚硝酸盐转运
Nitrate and nitrite transport in bacteria.
作者信息
Moir J W, Wood N J
机构信息
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.
出版信息
Cell Mol Life Sci. 2001 Feb;58(2):215-24. doi: 10.1007/PL00000849.
The topological arrangements of nitrate and nitrite reductases in bacteria necessitate the synthesis of transporter proteins that carry the nitrogen oxyanions across the cytoplasmic membrane. For assimilation of nitrate (and nitrite) there are two types of uptake system known: ABC transporters that are driven by ATP hydrolysis, and secondary transporters reliant on a proton motive force. Proteins homologous to the latter type of transporter are also involved in nitrate and nitrite transport in dissimilatory processes such as denitrification. These proteins belong to the NarK family, which is a branch of the Major Facilitator Superfamily. The mechanism and substrate specificity of transport via these proteins is unknown, but is discussed in the light of sequence analysis of members of the NarK family. A hypothesis for nitrate and nitrite transport is proposed based on the finding that there are two distinct types of NarK.
细菌中硝酸盐和亚硝酸盐还原酶的拓扑结构需要合成转运蛋白，这些转运蛋白可将氮氧阴离子转运穿过细胞质膜。对于硝酸盐（和亚硝酸盐）的同化作用，已知有两种类型的摄取系统：由ATP水解驱动的ABC转运蛋白，以及依赖质子动力的次级转运蛋白。与后一种转运蛋白同源的蛋白质也参与异化过程（如反硝化作用）中的硝酸盐和亚硝酸盐转运。这些蛋白质属于NarK家族，它是主要易化子超家族的一个分支。通过这些蛋白质进行转运的机制和底物特异性尚不清楚，但根据NarK家族成员的序列分析进行了讨论。基于发现存在两种不同类型的NarK，提出了一种关于硝酸盐和亚硝酸盐转运的假说。
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