Lee J W, Lee Y C, Na S Y, Jung D J, Lee S K
Center for Ligand and Transcription, Chonnam National University, Kwangju, Korea.
Cell Mol Life Sci. 2001 Feb;58(2):289-97. doi: 10.1007/PL00000856.
Nuclear receptors, many of which undergo a major conformational change upon binding specific ligand, belong to a superfamily of proteins that bind to specific DNA sequences and control gene transcription. They regulate the assembly of a transcriptional preinitiation complex at the promoter of target genes and modulate their expression in response to ligand. In particular, nuclear receptors repress or stimulate transcription by recruiting corepressor or coactivator proteins, in addition to directly contacting the basal transcription machinery. In this review, we discuss recent progress in studies of these transcriptional coregulators of nuclear receptors.
核受体属于一类蛋白质超家族，其中许多在结合特定配体后会发生重大构象变化，它们能与特定DNA序列结合并控制基因转录。它们在靶基因启动子处调节转录前起始复合物的组装，并根据配体调节其表达。特别是，核受体除了直接接触基础转录机制外，还通过招募共抑制因子或共激活因子蛋白来抑制或刺激转录。在本综述中，我们讨论了核受体这些转录共调节因子研究的最新进展。
