Kim H J, Lee T J, Kim M K, Choi Y H, Myung S C, Kim Y S, Song K Y
Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.
J Korean Med Sci. 2001 Feb;16(1):123-6. doi: 10.3346/jkms.2001.16.1.123.
This case reports muellerianosis of the urinary bladder, showing glandular lesions made up of endocervical type glands, in a 36-yr-old woman. The patient presented with lower abdominal discomfort and pain on voiding. The patient had undergone two Cesarean sections 5 yr and 3 yr earlier. On a pelvic ultrasonography, a well-circumscribed mass, 2.2x0.8 cm in dimension, was found with luminal polypoid projection in the posterior wall of the urinary bladder. The patient had a transurethral resection of the bladder mass. Histologically, the tumor was composed of irregularly shaped glands lined by endocervical mucous epithelium in the muscularis propria of the urinary bladder. Some glands exhibited cystic dilatation and contained mucinous secretions. The glands elicited no desmoplastic tissue reaction. The intraluminal mucin often contained polymorphonuclear leukocytes. The glands were mostly lined by tall columnar and bland looking mucous cells with mucin secretion. The ciliated cells were rarely observed. No endometrial component is noted. It would be appropriate to designate this lesion as "Muellerianosis of the urinary bladder, endocervicosis type". Awareness of the lesion and attention to its typical histologic features should facilitate its crucial distinction from adenocarcinoma.
本病例报告了一名36岁女性膀胱苗勒管化生,表现为宫颈内膜样腺体构成的腺性病变。患者出现下腹部不适及排尿疼痛。该患者在5年前和3年前分别接受过两次剖宫产手术。盆腔超声检查发现膀胱后壁有一大小为2.2×0.8 cm、边界清晰的肿块,腔内呈息肉样突出。患者接受了经尿道膀胱肿块切除术。组织学检查显示,肿瘤由膀胱固有肌层内不规则形腺体组成,内衬宫颈内膜黏液上皮。部分腺体呈囊性扩张,含有黏液性分泌物。腺体未引发促纤维增生性组织反应。腔内黏液常含有多形核白细胞。腺体大多内衬高柱状且外观温和的黏液细胞,有黏液分泌。很少观察到纤毛细胞。未发现子宫内膜成分。将此病变命名为“膀胱苗勒管化生,宫颈内膜化生型”是合适的。认识该病变并关注其典型组织学特征应有助于与腺癌进行关键鉴别。