Herr H, Kim J U, Kang G H, Moon K C, Koh J K
Department of Dermatology, Asan-Foundation Kangnung Hospital, Korea.
J Korean Med Sci. 2001 Feb;16(1):130-4. doi: 10.3346/jkms.2001.16.1.130.
Kaposi's sarcoma (KS) appears to develop in association with kidney transplantation, but unlikely with dialysis. We report two cases of classic KS that occurred in patients receiving short-term (less than 3 yr) dialysis. They have been suffering from chronic renal failure due to tuberculosis and diabetes mellitus, respectively. Several to multiple, reddened-violaceous patches, plaques and nodules were found on the hand and the lower extremities. Laboratory studies showed no evidence suggesting immunosuppressed state and there was no history of taking immunosuppressive agents. The biopsies of the two cases revealed proliferation of spindle-shaped cells focally arranged in bundles and multiple dilated vascular spaces outlined by an attenuated endothelium with intravascular and extravasated erythrocytes. The specimens expressed positivity with CD34 antigen. Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) was detected in one case by polymerase chain reaction method.
卡波西肉瘤（KS）似乎与肾移植相关，但与透析关系不大。我们报告两例经典型KS发生在接受短期（少于3年）透析的患者中。他们分别因结核病和糖尿病患有慢性肾衰竭。在手部和下肢发现了数个至多个红紫色斑块、丘疹和结节。实验室检查未发现提示免疫抑制状态的证据，且无服用免疫抑制剂的病史。两例活检显示梭形细胞增殖，局部呈束状排列，并有多个扩张的血管间隙，其内皮变薄，有血管内和血管外红细胞。标本对CD34抗原呈阳性表达。通过聚合酶链反应法在一例中检测到人类疱疹病毒8型（卡波西肉瘤相关疱疹病毒）。
