Pleasure J R, Blackburn M G
Pediatrics. 1975 Apr;55(4):503-6.
A 27-year-old woman who was 34 weeks pregnant was admitted in a semicomatose state. Five days later she gave birth to an infant who demonstrated significant CNS depression. Elevated blood levels confirmed bromide intoxication in both the mother and infant secondary to chronic maternal bromide ingestion (Nervine). Simultaneous determinations revealed a higher initial serum bromide level in the infant compared to that of the mother in spite of a subsequent more rapid rate of disappearance in the neonate. It is suggested that the drug history obtained from the pregnant woman include nonprescription medications containing bromides. This possibility should also be included in the differential diagnosis in infants exhibiting evidence of CNS depression, particularly those born to mothers classified as neurotic or psychotic.
一名怀孕34周的27岁女性以半昏迷状态入院。五天后，她生下一名有明显中枢神经系统抑制症状的婴儿。血液水平升高证实母婴均因母亲长期摄入溴化物（Nervine）而发生溴中毒。同时测定发现，尽管新生儿随后溴化物消失速度更快，但婴儿初始血清溴化物水平高于母亲。建议从孕妇处获取的用药史应包括含溴化物的非处方药。对于有中枢神经系统抑制迹象的婴儿，尤其是母亲被归类为神经症或精神病患者所生的婴儿，鉴别诊断中也应考虑这种可能性。
