Pouillart P, Schwarzenberg L, Amiel J L, Mathé G, Huguenin P, Morin P, Baron A, Laparre Ch, Parrot R
Nouv Presse Med. 1975 Mar 8;4(10):717-9.
16 patients suffering from primary bronchial tumours which had recurred after surgery and/or radiotherapy and with spread involving at least one visceral or lymphatic metastasis received chemotherapy consisting of the administration of vincristine followed by a combination of CCNU and 5-fluorouracil. Each cycle of treatment lasted 6 days and was restarted only after an interval of 30 days on average, this being necessary for haematological recovery. With the doses of CCNU used, thrombocytopaenia occurred only during the fifth cycle of treatment and made it necessary to increase the interval between subsequent courses to five weeks. All of the patients included in the study have now been followed up for between six and eighteen months. Two patients are presently in complete remission without apparent radiological, clinical or bronchoscopic signs. In seven other patients there was tumour regression greater than 50 p.cent persisting for four to six months. In seven, the therapeutic effect was transient or nil.
16例原发性支气管肿瘤患者在手术和/或放疗后复发，且有扩散，至少涉及一处内脏或淋巴转移，接受了化疗，化疗方案为静脉注射长春新碱，随后联合使用洛莫司汀（CCNU）和5-氟尿嘧啶。每个治疗周期持续6天，平均仅在间隔30天后重新开始，这对血液学恢复是必要的。使用洛莫司汀的剂量时，血小板减少仅在第五个治疗周期出现，因此有必要将后续疗程之间的间隔延长至五周。纳入该研究的所有患者目前均已随访6至18个月。两名患者目前完全缓解，无明显影像学、临床或支气管镜检查体征。另外七名患者的肿瘤缩小超过50%，持续四至六个月。七名患者的治疗效果是短暂的或无效的。
