吗啡和哌替啶对小鼠体温的影响以及利血平对小鼠体温影响的逆转作用的比较。

A comparison of the effects of morphine and pethidine upon body temperature and the reversal of reserpine's effects upon body temperature in the mouse.

作者信息

Menon A M, Pleuvry B J

出版信息

J Pharm Pharmacol. 1976 Nov;28(11):827-31. doi: 10.1111/j.2042-7158.1976.tb04065.x.

DOI:10.1111/j.2042-7158.1976.tb04065.x

Abstract

The effects of morphine and pethidine upon body temperature and upon the reversal of reserpine hypothermia in the mouse were investigated. Both morphine and pethidine produced a dose-dependent fall in body temperature, that of morphine being totally antagonized by nalorphine and partially by naloxone, while that of pethidine was antagonised by naloxone and enhanced by nalorphine. Both drugs reversed reserpine-induced hypothermia. The reversal by morphine, but not by pethidine, was partially antagonized by naloxone. Adrenalectomy prevented the reversal of reserpine hypothermia by pethidine but morphine produced a partial reversal. Ganglion blockade and alpha-and beta-blockade all prevented reversal of reserpine hypothermia by both drugs. The results are discussed with regard to differences between pethidine and morphine and possible involvement of opiate receptors.

摘要

研究了吗啡和哌替啶对小鼠体温以及对利血平所致体温过低的恢复作用。吗啡和哌替啶均引起体温呈剂量依赖性下降，吗啡引起的体温下降可被烯丙吗啡完全拮抗，被纳洛酮部分拮抗，而哌替啶引起的体温下降则被纳洛酮拮抗，并被烯丙吗啡增强。两种药物均可使利血平诱导的体温过低恢复。吗啡引起的恢复作用（而非哌替啶引起的）可被纳洛酮部分拮抗。肾上腺切除术可阻止哌替啶使利血平所致体温过低恢复，但吗啡可产生部分恢复作用。神经节阻断以及α和β阻断均阻止两种药物使利血平所致体温过低恢复。就哌替啶和吗啡之间的差异以及阿片受体可能的参与情况对结果进行了讨论。