Coppings R J, Malven P V
Proc Soc Exp Biol Med. 1975 Jan;148(1):64-8. doi: 10.3181/00379727-148-38477.
Exogenous ovine LH was constantly infused during 6-hr experimental sequences in order to determine the effect of elevated levels of plasma LH on the pulsatile discharges of pituitary LH characteristic of ovariectomized sheep. Plasma LH concentrations (exogenous plusendogenous) in sequential 10-min samples continued to fluctuate significantly as did plasma LH (endogenous only) during control periods. The temporal patterns of plasma LH during LH infusion were at least as as rhythmic as they were in the controls. Furthermore, the mean periods for extremely rhythmic frequencies were equivalent in control and LH-infusion sequences. These data refute the original hypothesis that inhibitory short-looped feedback of circulating LH governs the timing of subsequent LH discharges in ovariectomized sheep.
在6小时的实验过程中持续输注外源性羊促黄体激素（LH），以确定血浆LH水平升高对去卵巢绵羊垂体LH脉冲式释放特性的影响。连续10分钟样本中的血浆LH浓度（外源性加内源性）持续显著波动，如同对照期仅内源性血浆LH的波动情况一样。LH输注期间血浆LH的时间模式至少与对照期一样具有节律性。此外，对照期和LH输注期的极有节律频率的平均周期是相等的。这些数据驳斥了最初的假设，即循环LH的抑制性短反馈回路控制去卵巢绵羊随后LH释放的时间。
