Day N P, Moore C E, Enright M C, Berendt A R, Smith J M, Murphy M F, Peacock S J, Spratt B G, Feil E J
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Science. 2001 Apr 6;292(5514):114-6. doi: 10.1126/science.1056495.
Staphylococcus aureus is a major cause of severe infection in humans and yet is carried without symptoms by a large proportion of the population. We used multilocus sequence typing to characterize isolates of S. aureus recovered from asymptomatic nasal carriage and from episodes of severe disease within a defined population. We identified a number of frequently carried genotypes that were disproportionately common as causes of disease, even taking into account their relative abundance among carriage isolates. The existence of these ecologically abundant hypervirulent clones suggests that factors promoting the ecological fitness of this important pathogen also increase its virulence.
金黄色葡萄球菌是人类严重感染的主要病因，但很大一部分人群携带该菌却没有症状。我们使用多位点序列分型来鉴定从无症状鼻腔携带以及特定人群中严重疾病发作时分离出的金黄色葡萄球菌菌株。我们鉴定出一些常见的携带基因型，即使考虑到它们在携带菌株中的相对丰度，这些基因型作为疾病病因也格外常见。这些在生态学上大量存在的高毒力克隆的存在表明，促进这种重要病原体生态适应性的因素也会增加其毒力。
