Gardner W U, Eisenfeld A J
Proc Soc Exp Biol Med. 1975 Mar;148(3):909-12. doi: 10.3181/00379727-148-38658.
The sensitivity of the vaginal epithelium of ovariectomized mice of the A and C57 strains to estradiol differ approximately fivefold. The vaginas of the more sensitive C57 strain did accumulate more 333H-E2 at 1 hr in two or three experiments but the retention at 6 and 12 hr was not significantly different. The pituitary accumulation of H-E2 by the pituitary-tumor susceptable C57 mice, although not significantly greater than that of the nonsusceptable A strain mice at 1 hr was higher at 6 and 12 hr after the injection. Most of the toluene extractable radioactivity from pituitary glands and vaginas was estradiol with no strain differences. The accumulation of H-E2 in other tissues was not significantly different in mice of the two strains.
A 品系和 C57 品系去卵巢小鼠的阴道上皮对雌二醇的敏感性相差约五倍。在两到三个实验中，更敏感的 C57 品系小鼠的阴道在 1 小时时确实积累了更多的³³³H-E2，但在 6 小时和 12 小时时的保留量没有显著差异。垂体肿瘤易感的 C57 小鼠垂体对 H-E2 的积累，虽然在注射后 1 小时并不显著高于不易感的 A 品系小鼠，但在 6 小时和 12 小时时更高。垂体和阴道中大部分可被甲苯萃取的放射性物质是雌二醇，品系间无差异。两种品系小鼠其他组织中 H-E2 的积累没有显著差异。
