Wiewiórowski M, Graczyk J
County Hospital Płock, 19 Medyczna Str., Poland.
Acta Pol Pharm. 2000 Nov;57 Suppl:138-9.
Methotrexate (MTX) is one of the most used medicines in rheumatoid arthritis [r. a.] treatment. There are many scientific reports which present influence of MTX on inflammatory process. In many centers influence of MTX on cytokines level have been investigated. Thanks to clinical studies it has been performed that MTX holds up activity and productions of Il-8, releasing of TNF-alpha and reduction of concentration Il-6. MTX holds up proliferation of monocytes, macrophages and synoviocytes. It has been indicated that MTX decreases synthesis of B-4 leucotrien in neutrophils, decreases level of neutral proteases, holds up cellular immunity and has antiproliferative influence on endothelial cells. There are reports, that MTX reduces expression of endothelial cells adhesive proteins and synthesis of chemotactic factors, stopping migration of leucocytes to tissues.
甲氨蝶呤（MTX）是类风湿性关节炎（RA）治疗中最常用的药物之一。有许多科学报告阐述了MTX对炎症过程的影响。在许多中心，MTX对细胞因子水平的影响已得到研究。通过临床研究发现，MTX抑制白细胞介素-8（Il-8）的活性和产生、抑制肿瘤坏死因子-α（TNF-α）的释放并降低白细胞介素-6（Il-6）的浓度。MTX抑制单核细胞、巨噬细胞和滑膜细胞的增殖。已表明MTX可降低中性粒细胞中白三烯B-4（B-4 leucotrien）的合成，降低中性蛋白酶水平，抑制细胞免疫，并对内皮细胞有抗增殖作用。有报告称，MTX可降低内皮细胞黏附蛋白的表达和趋化因子的合成，阻止白细胞向组织迁移。
