动脉粥样硬化繁殖雄性大鼠与非动脉粥样硬化未交配完整及去势雄性大鼠在异丙肾上腺素诱导心肌梗死后的代谢反应

Metabolic response after isoproterenol-induced myocardial infarction in arteriosclerotic breeder vs nonarteriosclerotic virgin intact and gonadectomized male rats.

作者信息

Lewis B K, Wexler B C

出版信息

Proc Soc Exp Biol Med. 1975 Apr;148(4):1177-83. doi: 10.3181/00379727-148-38712.

Abstract

Male, nonarteriosclerotic (virgin) intact and castrated, Sprague-Dawley rats and male, arteriosclerotic (breeder) rats were subjected to an acute and massive myocardial infarct, by treating them with two large, subcutaneous doses of isoproterenol, spaced 24 hr apart. Serum insulin and glucose rose abruptly after the first injection of isoproterenol, but not after the second injection. Free fatty acids rose, most markedly, in the intact, nonarteriosclerotic rats, less in the arteriosclerotic breeders, and least in the castrates. These changes in free fatty acids coincided with numerical survival, i.e., greatest number of survivors in castrates. The castrated males also manifested the least amount of congestive heart failure and showed the greatest capacity to affect myocardial repair. It is suggested that reduced androgen levels may have an ameliorative effect on the usual pathogenesis of isoproterenol-induced myocardial infarction in rats.

摘要

雄性、非动脉粥样硬化（未交配）的完整和阉割的斯普拉格-道利大鼠，以及雄性动脉粥样硬化（繁殖用）大鼠，通过皮下注射两剂大剂量的异丙肾上腺素（间隔24小时），使其遭受急性大面积心肌梗死。首次注射异丙肾上腺素后，血清胰岛素和葡萄糖水平急剧上升，但第二次注射后未出现这种情况。游离脂肪酸升高，在完整的非动脉粥样硬化大鼠中最为明显，在动脉粥样硬化的繁殖用大鼠中升高较少，而在阉割大鼠中升高最少。游离脂肪酸的这些变化与存活数量相符，即阉割大鼠中的存活者数量最多。阉割雄性大鼠还表现出最少的充血性心力衰竭，并且显示出对心肌修复的最大影响能力。提示雄激素水平降低可能对异丙肾上腺素诱导的大鼠心肌梗死的常见发病机制具有改善作用。