Wexler B C
Br J Exp Pathol. 1976 Dec;57(6):663-85.
Male and female nonarteriosclerotic (virgin) and arteriosclerotic (breeder) Sprague-Dawley rats were subjected to acute myocardial infarction with isoprenaline. When myocardial necrosis was most intense, animals were given cortisone (high and low doses), Dianabol, or Enovid. Animals receiving large doses of cortisone manifested the best survival rate during the early stages of myocardial infarction. Although their serum enzyme levels were least elevated and their hearts showed tha least amount of damage, these animals had undergone the most intense body weight loss and began to die suddenly during the later stages of the experiment. These animals also manifested hyperlipidaemia, hyperglycaemia, septicaemia, severe disuse atrophy of their adrenal glands, and reduced Cmpd. B production. Animals treated with low doses of cortisone or with the anabolic and androgenic steroid, Dianabol, manifested none of the myocardial pretective effects of the larger dose of cortisone. These animals displayed a high incidence of left ventricular aneurysm formation concomitant with extensive cartilaginous metaplasia within the aneurysmal sites. Treatment with the contraceptive drug, Enovid, caused body weight loss, hyperlipidaemia, hyperglycaemia, gonadal atrophy and reduction of Cmpd. B production. Although the high dose of cortisone exercised definite salutary effects during early myocardial infarction, chronic treatment led to adrenal disuse atrophy and hypoadrenocorticism associated with sudden death during the later stages of myocardial repair. These findings indicate that proper adjustment of the dose and chronicity of corticosteroids used for treating the crisis of acute myocardial infarction must be made in order to provide effective protection against untoward pathophysiological conditions, acceleration of myocardial repair, but without suppression of adrenal function.
对雄性和雌性未患动脉粥样硬化（未交配）及患动脉粥样硬化（已繁殖）的斯普拉格 - 道利大鼠用异丙肾上腺素诱导急性心肌梗死。当心肌坏死最为严重时，给动物注射可的松（高剂量和低剂量）、大力补或炔雌醇甲醚。接受大剂量可的松的动物在心肌梗死早期表现出最佳存活率。尽管它们的血清酶水平升高最少，心脏损伤也最小，但这些动物体重减轻最为严重，且在实验后期开始突然死亡。这些动物还表现出高脂血症、高血糖症、败血症、肾上腺严重废用性萎缩以及化合物B生成减少。用低剂量可的松或合成代谢及雄激素类类固醇大力补治疗的动物未表现出大剂量可的松的心肌保护作用。这些动物左心室动脉瘤形成的发生率很高，且动脉瘤部位伴有广泛的软骨化生。用避孕药炔雌醇甲醚治疗导致体重减轻、高脂血症、高血糖症、性腺萎缩以及化合物B生成减少。尽管高剂量可的松在心肌梗死早期有明确的有益作用，但长期治疗会导致肾上腺废用性萎缩和肾上腺皮质功能减退，并与心肌修复后期的突然死亡有关。这些发现表明，为了有效预防不良病理生理状况、加速心肌修复且不抑制肾上腺功能，必须适当调整用于治疗急性心肌梗死危机的皮质类固醇的剂量和用药时长。
